P 394 Hydrolization of the vitreoretinal interface by intravitreal TPA-injection following cryopexy

lesponses of the cells involved in &is process tue no, mmpletiy cleared. lk main goal of lhis study was to determine lipid pemxldation pmducu in tis fluid and uy IO establish any possible correlation with the differen, climcal feamres of the patients. spe&lly regarding myopia. since myopc patients sulk rctiml detachment 8.lold mat frequently lhan mm miopic pa&r&. MEIHODS: 38 patients (,9 men and 19 wamco) w,,h an age range 20.80 years old were randomlv selected and underwe,,, a comrdece oobthalmolonical examination. Thy wea dahied in 4 groups attending tqbpia &up I, no0 myopic padems: II: O-5 diopltie~; EI: S-10 diophies; IV: >I0 dicptrics). and olher clinical parameters such as oumbcr of breaks. macular affeuion, prcviws cakuac, surgery. ti&c elapsed Imn diagnosis to surgay. were also mnadezed lipid penxidarim, products presen, in SF were detamined as Ihe tiobabitic aid reactive subslance (IBARS). RESULTS: Mean TBARS rrmecnvBtic.n in SF of the pa,ie.tien,s studied WBS 12.60 + 8.15 p M, and that of proteins 12.01 f 5.86 mgind A high posiuve correlatioo exist bavem both paamelen (I= 0.73, pco.001). Group I” TBARS mnceowtion was statistically higher than the rest of the patients M groups sludted. The age mdadon, whmmnsidering the whole pqxktion showed a weak negative vdne. wheress when the high myopic patimta were omsidered separa,ely. the correlation tuned lo a positive weak value (r=OAO. pcO.05) in agreement w,h o,ber authors. No cm-relaooo was observed betwecn the TEIARS values and Ihe tune clapsed between diagnosis and surgery. or Ihe numba oi retinal breaks, as well as no ddfereace could be esrablished belween patients wilh affec,ed and non-affeckd mauda, considering myopes and mm myopea. CONCLUSIONS: Tbe presence of lipid pemxidadon pmduc,s allows dx proposal that at sme inioai stage. or during the whole parss. oxidauve damage is involved m [he pathophysiology of retinal dctacbment, and [bat this mechanism is more mlensive in miooic mJienls. ‘Pardally suppdned by a g&f fmm the FIS (!M/l629) 10 FJR FBM IS a research fellow lmm rhe Conselltia de Ed&6 t Ci&aa GeoeahM V;llenaana